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Thermal micro/nano poration system for transdermal drug delivery Yong-Kyu Yoon, Jung-Hwan Park, Jung-Woo Lee, Mark Prausnitz, Mark G. Allen We develop thermal skin ablation systems for transdermal drug delivery in both wired and wireless fashions. Especially a wireless induction heating system for generating micron-scale pores in the skin by thermal micro-ablation that seeks to combine the efficacy of wired approaches with the improved convenience and likely higher patient compliance of wireless power delivery. The separation between the power source and the heating elements provides the potential for design flexibility, such as easier integration of ablation heating components with the drug patches and removal of the inconvenience of being ‘plugged in’ to an energy source, while maintaining the advantages of thermal micro-ablation. Schematic diagram of wireless inductive heating system An array of hollow metallic posts (inner tip diameter of 100mm, metal thickness of 30mm, post height of 400mm) Histological section of a rat skin after thermal micro-ablation Sponsor: Tyco Healthcare Co. Other Projects: Gas flow system using thermal transpiration à Nano fiber/texture formation for artificial tissue engineering à Millimeter-wave antenna for system-on-chip (SOC) à
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