MicroSensors and MicroActuators Georgia Tech MEMS group
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Three-dimensional high-aspect-ratio cell culturing scaffolds (2004-2005) Yanzhu Zhao, Xiaosong Wu, Yong-Kyu Yoon, Mark G. Allen Biomaterials play an important role in medicine today with a broad range of applications that include: medical devices, artificial implants, drug delivery coatings, and cell scaffolds for tissue regeneration. The material surface is expected to support cell colonization, migration, growth, and differentiation, and to guide the development of the required tissue. The important factors governing surface properties include surface chemistry, mechanical strength, surface structure, degradation kinetics and biological factors. Each tissue/organ needs a specific and individual design with appropriate material properties. In this work, techniques based on micro-electro-mechanical system (MEMS) microfabrication have been used to fabricate matrices with high spatial resolution of 3-D structures. The processes investigated are a silicon deep-reactive ion etching (DRIE) process, an SU-8/polydimethylsiloxane(PDMS) process, and a multi-step SU-8 process. Wafer-scale implementation of bone cell culturing substrates is successfully demonstrated and successful duplication of hydrogels based on these molds is demonstrated.
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