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Electrically active electroporation microneedle array for gene delivery Seong-O Choi, Jung-Hwan Park, Yeuchun Kim, Harvinder S. Gill, Yong-Kyu Yoon, Mark R. Prausnitz, and Mark G. Allen Microneedles have been used for transdermal drug delivery, and reports indicate that they could be inserted into skin without pain. With proper metallization, microneedles could serve as microelectrodes, which are essential for electroporation. In addition, the close spacing of the microneedle electrodes provides an advantage of reduced voltage while simultaneously maintaining the large electric fields required for electroporation. With these advantages, microneedles can potentially be utilized as a minimally invasive, highly-localized electroporation system for cells in epidermis Concept of device PMMA microneedle array Electrically active microneedle array SEM picture of the device 3-D microstructures fabricated by inclined UV exposure and micromolding Sponsors: NIH Other Projects: 3D Multi-electrode and fluidic arrays for neuronal culturing, stimulation and recording
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